Nutritional Perspectives

Nutritional Perspectives is a peer-reviewed journal that publishes original papers and review articles across the full range of nutritional science. The focus of all manuscripts submitted to the journal should be to increase knowledge in nutritional science relevant to human nutrition. Nutritional Perspectives welcomes manuscripts that report studies in nutritional epidemiology, nutritional requirements, metabolic studies, body composition, energetics, appetite and obesity. Manuscripts that address interactions of nutrition with endocrinology, genetics, immunology, microbiology, molecular and cell biology, neuroscience and physiology and that report outcomes relevant to health, behavior and well-being are also within scope for Nutritional Perspectives.


A Metabolic Point of View on Parkinson’s Disease

In my newsletter series on inflammation, insulin resistance, and neurologic illness, while many neurodegenerative ailments were addressed, certainly the primary focus was Alzheimer’s disease. Others, such as Parkinson’s disease, were addressed, but not in nearly as much detail. In particular, given the incidence of Parkinson’s disease in the US, I feel it warrants more attention. Therefore, I was pleased to find a paper that addresses this ailment from a metabolic, allostatic load point of view, the recently published paper (February 2018) “Aging and Parkinson’s disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis” by Calabrese et al. The first quote I would like to feature from this paper discusses the significant frequency of Parkinson’s disease (PD):

Jeffrey Moss, DDS, CNS, DACBN

Clinical Case Study on Orally Administered Whey Protein Microencapsulated DIM in Castrate-resistant Metastatic Prostate

3,3′-Diindolylmethane (DIM), an active constituent of cruciferous vegetables and well regarded as a potent anticancer compound as well as an anti-androgen, modulates estrogen metabolism and down-regulates androgen receptors. It has been found to improve Quality of Life (QOL) in prostate cancer patients. Prostate cancer (PCa) is the most commonly detected malignancy among males in developed countries, accounting for 10% of all cancers in 2020, which represents 191,000 new cases. Because of the high prevalence, a randomized, placebo-controlled, single-blind design study was conducted with two parallel groups to determine the effect of the microencapsulated, enhanced orally administered DIM. This novel delivery system of this potent anticancer agent was found to improve the Quality of Life (QOL) of patients with a confirmed diagnosis of castrate-resistant prostate cancer. Among 20 patients, two parallel groups of 10 each, ages ranging from 60-71, histologically confirmed castrate-resistant prostate cancer (CRPC) were selected for this 6 week study. Patients within group I (cases) were prescribed whey protein microencapsulated DIM at a dose of 150 mg orally twice daily; group II (control) were administered a dose of 150 mg whey protein (placebo) twice daily. All the patients' Quality of Life (QOL) measurements, using EORTC QLQ-PR25 questionnaire, were determined before and after the study. Results indicated that a significant decrease ( P < 0.05) in the symptoms scale over the 6 week duration was observed in the urinary and hormonal-treatment-related symptoms of the group I (cases) after the active therapy as compared to group II (control). Additionally, a significant improvement over that time frame was observed in the sexual activity in the patients after the treatment; No significant adverse effects were reported by the patients during follow-up visits. Based on this clinical data, it is concluded that the whey protein encapsulated DIM may have the potential to delay the decline of Quality of Life (QOL) and, in some cases, even improve the Quality of Life in those patients with metastatic prostate cancer.

Adam Killpartrick, Abbas Khan, Imran Khan, Murad Zeb, Cuina Wang, and MingruoGuo

Natural Interventions To Treat Sleep Deprivation As A Risk Factor For Coronary Heart Disease. A Commentary on the Available Research

According to the World Health Organization ischemic heart disease is the leading cause of death in the world. This commentary will discuss natural remedies for insomnia which is a risk factor for coronary heart disease.

Adrian Isaza, PhD, MBBS


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