Are Chronic Inflammation and Its Metabolic Counterpart, Insulin Resistance, the Common Denominators for All Chronic Behavior and Neurodegenerative Disorders? A Review of the Evidence – Part II

In part I of this series I reviewed the paper “Immune aging, dysmetabolism, and inflammation in neurological diseases” by Deleidi et al in which it was stated that the key cell in the CNS that appears to be most responsible for much of the damage seen in the CNS as the result of chronic inflammation is the main innate immune cell of the brain, microglia. As noted by the authors, chronic inflammation can up-regulate activity of microglia leading to increased CNS inflammation and a whole host of mood, behavioral, and neurodegenerative disorders. In part II of this series I would like to discuss microglia in more detail by reviewing the paper “The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders” by Reus et al.