Hyperhomocysteinemia as a Result of the Methylenetetrahydrofolate reductase (MTHFR) C677T Polymorphism Causes an Increased Risk of Cerebrovascular Disease: A Biochemical Perspective.
Published on
January 1, 2011
Abstract
INTRODUCTION There is much investigation today into the relationship of elevated homocysteine and cardiovascular disease. Homocysteinemia is widely associated with cardiovascular disease in the form of atherosclerosis, myocardial infarction, peripheral arterial disease, venous thrombosis, hypertension, and cerebrovascular disease. Considerable speculation exists to the adverse effects of elevated homocysteine and neural tube defects, colorectal cancer, and dementia. This research paper is an attempt to explore homocysteinemia as a causative agent in cerebrovascular disease and stroke.