Periodic Fever Syndrome: A Case Study of Biofilm-Mediated Fever and Successful Treatment with Fibrinolytic Enzymes and Natural Antimicrobials

Periodic Fever Syndrome (PFS) is highlighted by a fever with or without additional symptoms. The underlying cause is suspected to be hereditary in nature from a genetic mutation. An underlying cause that is not commonly considered or diagnosed is a biofilm-related infection. A biofilm’s natural cycle of growth-release-repeat provides an episodic flow of microorganism into the body to cause a fever and the asymptomatic periods in-between typical in a PFS patient. The microorganisms being released can be bacterial, viral, fungal or a combination which triggers the periodic fevers while the biofilm acts as barrier hiding the infection from detection and drug therapies. A treatment protocol using fibrinolytic enzymes and a broad-spectrum antimicrobial may be an effective treatment for PFS not associated